Class Explorer · Pain & inflammation
Simple analgesics
Acetaminophen's central COX action: analgesia and antipyresis without anti-inflammatory or antiplatelet effects.
Members
Compare the members
Acetaminophen
- Daily ceiling concept
- Hard maximum; lower in liver disease/alcohol
- Note
- Count all sources
Shared across the class
- Indications
- First-line mild-moderate pain · Fever
- Adverse effects
- Hepatotoxicity in overdose
- Contraindications
- Severe active liver failure
- Monitoring
- Total daily intake across all products
What makes each agent different
- The class of one: its comparison is with NSAIDs, and the trade is efficacy ceiling for organ safety.
Every combination cold product is an acetaminophen dose in disguise.
Last reviewed 2026-08-15 · Goodman & Gilman's The Pharmacological Basis of Therapeutics, 14th ed.