Class Explorer · Gastrointestinal
Proton pump inhibitors
Irreversible H+/K+-ATPase inhibition in active parietal cells: the deepest acid suppression available.
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OmeprazoleThe proton pump inhibitor: profound acid suppression, and a deprescribing conversation waiting to happen.PantoprazoleThe proton pump inhibitor that stays out of other drugs' way.
Also in this class: Pantoprazole (fewest interactions) · Esomeprazole · Lansoprazole · Rabeprazole. Full pages arrive as the library grows.
Compare the members
Omeprazole
- CYP2C19 effect
- Substrate + inhibitor
- Distinguishing point
- The clopidogrel-caution member
Shared across the class
- Indications
- GERD · Peptic ulcer disease · H. pylori regimens · NSAID gastroprotection
- Adverse effects
- Headache, GI upset · Rebound hypersecretion on stopping · Long-term associations (B12, magnesium, C. difficile, fractures)
- Contraindications
- Rilpivirine co-administration
- Monitoring
- The indication itself, at every renewal · Magnesium if long-term and symptomatic
What makes each agent different
- Pantoprazole's weak CYP2C19 footprint makes it the default beside clopidogrel.
- Efficacy differences are marginal; duration-of-need differences are everything.
A PPI without a stop date is a medication-review finding, not a maintenance plan.
Last reviewed 2026-08-15 · Goodman & Gilman's The Pharmacological Basis of Therapeutics, 14th ed.